Discipline of Infectious Diseases



• An international multicentre prospective observational study of the immunopathogenesis of immune

     restoration Disease in severely immunodeficient HIV patients commencing antiretroviral therapy

     (MIRSAT).“ The focus at the Durban site is identify patients with cryptococcal meningitis who deteriorate

      following antiretroviral treatment with a view studying various immunological parameters which is

      expected to contribute to the understanding of the immunopathogenesis of this syndrome. This study will

      form the basis for a PhD for a student from Monash University, Australia who is being hosted in the

      Department of Infectious Diseases.

• Diagnosis of smear negative HIV associated pulmonary tuberculosis: Comparison of swallowed sputum

    sample obtained by enteric capsular device with induced sputum.

• Clinical and mycological predictors of cryptococcosis-associated immune reconstitution inflammatory syndrome. (Cryptococcal)
•Circulating inflammatory biomarkers can predict and characterize tuberculosis-associated immune

     reconstitution inflammatory syndrome (IRIS).

•Operationalizing early antiretroviral therapy in HIV-infected in-patients with opportunistic infections including tuberculosis